21. It is concluded that PCNA immunocytochemistry may be used as an operational marker of cell proliferation in normal colonic mucosa. 22. In this study on biopsy samples from colonic mucosa of patients with no colonic disorders, the comparison between two methods of assessing cell proliferation showed a significant correlation. 23. Various kinds of cytokines may be involved in causing the inflammation of colonic mucosa in ulcerative colitis. 24. The treatment with corticosteroid is suggested to be effective through the inhibition of anticolon ADCC in the colonic mucosa. 25. Contamination of isolated cell membranes with intracellular components would therefore probably result in the detection of pre-Beta chains in the normal colonic mucosa. 26. Two studies have shown that in inflammatory bowel disease the concentrations of arachidonic acid in the inflamed colonic mucosa were increased. 27. Ultrastructural changes in colonic mucosa consistent with increased absorption have been described in ulcerative colitis, in both affected and unaffected areas. 28. We reported recently that colonic mucosa from patients with ulcerative colitis produce high values of platelet activating factor, a potent proinflammatory lipid mediator. 29. Most investigators use the proliferative pattern of the rectal mucosa as a reliable index of the cytoproliferative activity of the entire colonic mucosa. 30. We also examined whether upward expansion actually occurred in the background colonic mucosa by ex vivo autoradiography. |