1.   These hydrophobic surfactantsmay damage colonic epithelial cells and consequently stimulate the proliferation of colonic crypt cells, which may increase the risk of colon cancer.

2.   Colonic crypt cell proliferation is used as an indicator of risk of colorectal carcinoma.

3.   Vitamic C or beta-carotene supplementation, however, significantly reduced the total proliferation whereas vitamin E supplementation hadno effect on the colonic crypt cell proliferation.

4.   This study assessed the effect of antioxidant vitamin supplementation on colonic crypt cell proliferation in patients with adenomatous polyps of the colon.

5.   In conclusion this study has shown that both Beta -carotene and vitamin C supplementation reduce the abnormal colonic crypt cell proliferation found in subjects with adenomatous polyps.

6.   Therefore, some investigators have examined the role of dietary calcium in influencing colonic crypt cell kinetics, since the latter may be a marker of neoplastic predisposition.

7.   Differences between the cululative BrdUrd labelling distributions of the colonic crypts of both groups were analysed by two sample, two tailed Kolmogorov-Smirnov test.

8.   There are many reports of studies on the phase of DNA synthesis in normal colonic crypts, but none on the DNA distribution in epithelial cells in colonic crypts.

9.   Colonic crypts were easily separated from lamina propria mucosa by agitating fragments of mucosa obtained by incubation with EDTA.

10.   No cells synthesising DNA are present in the upper one third and surface epithelium of normal colonic crypts.