1. Similarly, infusion of PYX did not prevent bile inhibition of ileal motor activity. 2. This suggested that bile inhibition of ileal motor activity was mediated by a humoral agent from the terminal ileum present in the venous effluent. 3. We therefore suggested that PYY might mediate the bile inhibition of ileal motility. 4. Furthermore, preinfusion of PYX, a specific competitive antagonist of PYY, did not reduce bile inhibition of ileal motor activity. 5. Other regulatory peptides in the terminal ileum may mediate bile inhibition of ileal motility. |
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