1.   Luminal bile and taurocheodeoxycholic acid inhibited ileal motor activity.

2.   This shows the presence of a humoral inhibitor of ileal motor activity.

3.   Intra-arterial infusion of PYX did not significantly change carbachol stimulated ileal motor activity.

4.   Similarly, infusion of PYX did not prevent bile inhibition of ileal motor activity.

5.   This suggested that bile inhibition of ileal motor activity was mediated by a humoral agent from the terminal ileum present in the venous effluent.

6.   In contrast, infusion of taurodeoxycholic acid at these concentrations inhibited ileal motor activity.

7.   These results indicated that bile and TDCA inhibited terminal ileal motor activity by a mechanism that was not mediated by PYY, enteroglucagon, or VIP.

8.   These findings suggested that bile and taurodeoxycholic acid directly inhibited ileal motor activity.

9.   Furthermore, preinfusion of PYX, a specific competitive antagonist of PYY, did not reduce bile inhibition of ileal motor activity.