1.   Cyclical changes in H pylori infection may cause the variations in basal acid secretion that are seen in duodenal ulcer disease.

2.   This is because this analysis excludes the effect of changes in basal acid secretion, which is thought to be independent of gastrin dependent.

3.   We have also shown for the first time such treatment also decreases basal gastric acid secretion significantly.

4.   Thus H pylori infection combined with active ulceration may cause the increased basal acid secretion seen in duodenal ulcer disease.

5.   The fall in basal acid secretion found may not necessarily be due to the eradication of H pylori.

6.   There has been debate as to whether this should be calculated with or without subtraction of basal acid secretion.

7.   It is widely held that the increased basal acid secretion in patients with duodenal ulcer disease is determined by vagal drive rather than circulating gastrin.

8.   Basal secretion was measured before the induction of the submaximal plateau -- formal maximal studies were not performed as this would have made the test unacceptably long.