1. Neuropeptide Y has also been reported to increase substantially gastric acid and pancreatic exocrine secretion. 2. In the case of pancreatic secretion, stimulation of bicarbonate but not protein output was observed. 3. This apparently selective effect on alkaline pancreatic secretion is similar to the specific effect of intracerebroventricular neuropeptide Y on the biliary bicarbonate observed in these studies. 4. Pancreatic secretion was examined in rats with chronic pancreatic fistula prepared as described previously. 5. This cannula was connected to another polyethlene cannula placed in the duodenum to permit the circulation of the pancreatic secretion into the duodenum. |