1.   Informed parental consent was obtained before the study.

2.   The study was approved by the Western Infirmary ethics committee and each patient gave informed written consent.

3.   All subjects gave informed written consent before the study.

4.   The procedure was reviewed and accepted by the Hospital Medical Ethics and Radiation Safety Committees and informed signed consent was obtained from each patient.

5.   Informed written consent was obtained and the experimental techniques were approved by the Salford Health Authority Ethics Committee.

6.   Informed written consent was obtained before the study.

7.   The study was approved by the local Ethics Committee and informed written consent was obtained from all subjects.

8.   All subjects gave fully informed written consent.

9.   All gave fully informed written consent.