1. Studies to measure human gastric crypt or gland cell proliferation may have a number of practical clinical applications in relation to both benign and malignant gastric conditions. 2. Some aspects of the sequence of migration and differentiation of cells in mammalian gastric crypts have been reported. 3. The relative complexity of gastric crypt anatomy compared with colorectal mucosa has discouraged its use as an experimental model in proliferation research. 4. The anatomy of gastric crypts varies through the stomach. 5. BrdUrd labelling was confined to the superficial zone of human gastric crypts. 6. There is no simple method to assess proliferation in single gastric crypts. 7. S phase gastric crypt cells display BrdUrd consistently. |
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