1.   Many single gene inherited diseases are caused by mutations which affect hepatic function, including haemophilia, phenylketonuria, and many of the disorders of cholesterol metabolism.

2.   These findings would suggest that an interplay of various intraluminal factors, including bile acids themselves, may affect colonic function.

3.   We conclude that autonomic neuropathy can affect motor functions throughout the gastrointestinal tract.

4.   For instance, high glucose concentrations stimulate insulin secretion in healthy volunteers and hyperinsulinemia affects gastrointestinal function.

5.   This is released by macrophages and neutrophils that infiltrate the colonic mucosa in large numbers during active ulcerative colitis and may affect the function of underlying smooth muscle.

6.   This may contribute to the urgency to stool often associated with ulcerative colitis if inflammatory cells release NO in sufficient amounts to affect sphinteric function.

7.   These cytokines may affect the functions of immunocompetent cells to induce colonic injury or induce the lysis of colonic epithelial cells directly.

8.   We all recognise that emotion affects gut function.

9.   Because of the location of her lesion, Moss was able to take more tissue around the tumor without worrying about affecting motor functions.

10.   But it can be tricky to infer brain functions from such chance findings because the destroyed areas may be only indirectly affecting a function like reading.