11.   It is unlikely that the effect of cholesteryl esters on pancreatic lysosomes is an artefact related to release of free fatty acids during preparation or incubation of phosphatidylcholine vesicles.

12.   The maximum concentration of free fatty acids to which the lysosomes were exposed did not disrupt pancreatic lysosomes after in vitro incubation.

13.   The mechanism whereby cholesteryl esters decrease the stability of pancreatic lysosomes is not known.

14.   The lack of an acute effect of ethanol or acetaldehyde on pancreatic lysosomes in vitro, however, does not exclude the potential pancreatotoxicity of these compounds in vivo.