1.   Amylase secretion was significantly lower, however, in the post-acute pancreatitis patients.

2.   When comparing the group of patients who had had a single attack with the control group, there was no significant difference in amylase secretion.

3.   We have shown that after acute pancreatitis, amylase secretion was decreased whereas trypsin, lipase, and bicarbonate secretion were not.

4.   Negative feedback inhibition would therefore explain the greater sensitivity of amylase secretion for the detection of pancreatic disease.

5.   While indomethacin alone did not affect amylase secretion, together with cyclosporin A it caused significant inhibition of enzyme secretion.

6.   Whether the noxious effect of cyclosporin A on amylase secretion is the consequence of reduced insulin release, is not known.