1. This study examined whether the phospholipid composition of the full thickness gastric mucosa is changed in peptic ulcer disease and gastritis. 2. There was no significant difference in phospholipid composition between antral and duodenal sites in duodenal ulcer patients. 3. In conclusion, the phospholipid composition of gastric mucosa changes in human gastrointestinal diseases but its relation to cellular functions needs further study. 4. Data on the phospholipid composition in gastric mucosa differ, but there is general agreement on the predominance of phosphatidylcholine and phosphatidylethanolamine. 5. We investigated the total phospholipid composition of human gastric mucosa from endoscopic biopsy specimens in patients with peptic ulcer disease or gastritis, and in normal subjects. 6. There was no difference in the phospholipid composition between antral and duodenal sites in patients with duodenal ulcer. 7. Recently, Schmitz and Renooij analysed the phospholipid composition of the gastric mucosa in surgical samples from four patients who had partial gastrectomy for peptic ulcer. |
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