1.   The control subjects did not receive either placebo or loperamide oxide tablets but underwent an identical series of measurements on one occasion.

2.   After treatment with loperamide oxide the number of bowel actions was still greater in the patients than in the control subjects but the stool weight was less.

3.   Bile acid absorption was increased appreciably by loperamide oxide and, after treatment, was not significantly different from values in the control group.

4.   In contrast, loperamide oxide delayed both small intestinal and whole gut transit.

5.   During treatment with loperamide oxide, small intestinal transit and whole gut transit were not significantly different from the control group.

6.   There were significant relationships between stool weight and both whole gut transit and stool frequency during treatment with loperamide oxide.

7.   An effect of loperamide oxide on intestinal secretion cannot be excluded as this was not examined.