1.   But the biggest innovation in wound closing came last year with the introduction of a tissue adhesive, Dermabond.

2.   His biggest innovation is in welfare.

3.   Perhaps the biggest innovation at Winn is the continuing experimentation with programs to try to give prisoners marketable skills.

4.   The biggest innovation is an area called On Stage, which mimics the structure of TV networks.

5.   Unquestionably, the biggest single innovation is a procedure called polymerase chain reaction, or P.C.R.

6.   This was supposed to be the biggest innovation in the sport since jumpers began covering greater distances with the V style.