1. Omeprazole effectively suppressed the gastric acid response to pentagastrin. 2. Studies with intragastric titration have noted an immediate acid secretory response to ethanol instillation before systemic absorption can occur. 3. Histamine has long been considered a putative mediator of the gastric acid secretory response to ethanol. 4. We therefore studied acid secretory responses to gastrin in a series of patients with duodenal ulcer disease before and after treatment to eradicate H pylori. 5. Acid secretory responses to gastrin were measured within five days of endoscopy. 6. The acid response to gastrin releasing peptide was again consistent in the four groups at each of the infusion rates of gastrin releasing peptide studied. 7. The pepsin response to gastrin releasing peptide showed the same pattern as the acid response at each infusion rate of gastrin releasing peptide. 8. The exaggerated acid response to gastrin can be explained by the increased parietal cell mass present in duodenal ulcer patients. 9. He also gave a couple of acid responses to two groups of protesters for liberal causes. |