61.   Hughes is convincing in his argument that the Cold War had a profound effect through technology on social organization.

62.   I cannot recall any other television program that has had such a profound effect on me, even with its very short run.

63.   However, the loss of Stafford had a profound effect on his teammates, who took their game to another level.

64.   In any case, their passing on has had a profound effect on me.

65.   In a stroke of inspired good fortune, biologists have found a gene that turns out to exert profound effects on the social behavior of mice.

66.   In the category of designed things that architecture critics usually ignore but that have a profound effect on the quality of life, airplanes and airports rank high.

67.   In the decade since the law was passed, it has had a profound effect on museums and the philosophy on which they are based.

68.   Individually, few of the riders would have a profound environmental effect, but together they constitute a serious threat.

69.   It had a profound effect on him and he had some deep feelings about the way he had been treated.

70.   It had a profound effect on Mr. Clark.