1.   But it had a profound effect on the child care service of the time.

2.   His writings indeed had a profound effect on others whose names appeared on the list.

3.   Ideas about baby feeding and weaning are constantly changing and actual practice can have a profound effect on child health.

4.   Rapid production of such large amounts of material clearly has profound effects on the land round the volcano.

5.   Taken together, different combinations of presidential, electoral, and party systems can have profound effects on democratic performance.

6.   That must have a profound effect on the ozone layer.

7.   The changes have had a profound effect.

8.   The speculation had an even more profound effect on the public sector.

9.   This would have a profound effect on company organization.