1. Consequently, the lytic activity of faecal water was decreased. 2. The protective effects of dietary calcium on the lytic activity of faecal water and on colonic proliferation have been ascertained in many rodent and human studies. 3. In addition, to determine the dietary effects on the cytolytic potency of the intestinal contents, luminal lytic activity was measured as lysis of erythrocytes by faecal water. 4. Phosphate supplementation of the intermediate and high calcium diets increased the soluble phosphate value, but decreased the pH of faecal water. 5. The logarithm of the concentration product of calcium and phosphate was negatively correlated with the pH of faecal water. 6. In creased dietary calcium decreased the fatty acid concentration in faecal water. 7. The bile acid concentration in faecal water also decreased with increasing dietary calcium, and this was not influenced by dietary phosphate. 8. The lytic activity of faecal water was high on the low calcium diets. 9. Our results are in accordance with other studies in rodents, which showed that dietary supplementation with calcium phosphate inhibits lytic activity of faecal water and colonic proliferation. |
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