1.   The mucosa of the pelvic ileal reservoir undergoes adaptive changes -- inflammatory, architectural and metaplastic -- on exposure to the faecal stream.

2.   The formation of a pelvic ileal reservoir results in pathological changes in the ileal mucosa in most patients regardless of the initial diagnosis.

3.   Pelvic ileal reservoirs have been shown to express colonic phenotypic changes and it has been suggested that the reservoir mucosa undergoes complete colonic metaplasia.

4.   These distributions were studied in an unselected patient group with pelvic ileal reservoirs constructed for both ulcerative colitis and FAP.

5.   Construction of a pelvic ileal reservoirwith ileo-anal anastomosis creates a functioning neorectum out of the terminal ileum.

6.   Various microbiological changes have been observed in pelvic ileal reservoirs, although these have not been consistent.

7.   A consistent feature of pelvic ileal reservoirs is the difference in inflammatory scores, particularly of active inflammation, between patients with ulcerative colitis and those with FAP.