1.   A typical advertisement this month in The Fayette Chronicle appealed to residents who had used two popular arthritis drugs.

2.   Centocor Inc. of Malvern, Pa., hopes to file for approval of a somewhat similar arthritis drug called Avakine within a year from now.

3.   Doctors are beginning to worry that Vioxx and Celebrex, two wildly popular arthritis drugs, may not be as safe as they were initially believed to be.

4.   He was expecting BASF to announce a marketing partner for its arthritis drug and thought the negotiations had become grist for the rumor mill.

5.   Hoechst Marion Roussel Inc., an American unit of Hoechst AG, meanwhile, recently applied for approval to market still another new arthritis drug, called Arava.

6.   If Amgen acquires Immunex and attempts to market its arthritis drug Kineret with Enbrel, the newly formed company could run into a morass of antitrust problems.

7.   Interest was further heightened Wednesday when IDEC Pharmaceuticals of San Diego and SmithKline Beecham of Philadelphia suspended testing on a rival arthritis drug called Primatizid.

8.   Monsanto has several new pharmaceutical products in the pipeline, including arthritis drugs and hormone replacement therapy treatment.

9.   One favorite is Immunex Corp., which makes an arthritis drug recently approved by the Food and Drug Administration.

10.   Pfizer is not including Celebrex, a popular arthritis drug, in the program, because that drug is actually made by Pharmacia and marketed by Pfizer.