1. There are no studies on the acute effect of alcohol intake on gastric acid secretion in chronic alcoholic patients. 2. All the results found in studies on non-alcoholic subjects may not hold true for chronic alcoholic patients. 3. The gastric acid secretory capacity in chronic alcoholic patients and those with alcoholic pancreatitis has been studied, with contradictory results reported by different studies. 4. Chey et al found hyposecretion of gastric acid or achlorhydria in chronic alcoholic patients without clinical or laboratory evidence of pancreatic disease. 5. Atrophic gastritis and superficial gastritis were more often seen in the alcoholic patients, which accounted for the hypochlorhydria seen in a group of these patients. 6. Acid hypersecretion found in a subgroup of alcoholic patients in these studies also occurred in dogs chronically given alcohol. 7. There are no studies on the effect of acute alcohol intake on gastric secretion in the chronic alcoholic patient. |