1.   Alcohol and drugs almost ruined his career.

2.   And finally the bloodied body of the victim is carried out of town, a reputation besmirched, a political career ruined.

3.   Any kind of sharp practice or dishonest dealing will infallibly ruin his career.

4.   He had been found guilty by inferred accusation, and this had ruined his career.

5.   His blend of smears, half truths and downright lies ruined many careers in government and the professions.

6.   His career had been ruined by the sensational and damaging stories that appeared in the popular press.

7.   If you insist, we shall rigidly enforce that provision, in the courts if necessary which would ruin your career once and for all.

8.   Not sure I want to - it would ruin his career.

9.   The scandal ruined the careers of several leading politicians.

10.   Then they would move on to acquaintances who were ruining their careers doing television.