1.   Indeed, the child was rattling and bubbling, coughing weakly and obviously in great discomfort.

2.   Why lodge him here thus roughly but not in any great discomfort?

3.   More often than not, great physical discomfort and the hint of danger also accompanied his pursuits.

4.   The divisions between Mingus and the rest of the world gave him great discomfort.

5.   The Supreme Court, for nearly two centuries the place where the uncomfortable questions of American culture have been resolved, has just created a great national discomfort zone.

6.   The tumors can grow, cause great discomfort and could jeopardize fertility.

7.   The worst-case scenario occurred, an invasive procedure that left Ramon with great discomfort and misgivings the morning after.

8.   To produce his last strips, he needed to wear special contact lenses that caused great discomfort and to work with a magnifying glass.

9.   Untreated, they often cause great discomfort.