61.   How the next U.S. president would seize that opportunity should be a defining issue of the presidential campaign.

62.   However, do not make an issue of refusing a drink.

63.   However, he said there is an open issue of how such a construction project would be financed.

64.   However, the whole issue of long work hours was so embedded in the culture that few firms dared break the pattern.

65.   I have not chosen to make an issue of such distinctions here.

66.   I was not prepared to agree that Britain could be outvoted on any substantive issue of foreign policy.

67.   I will attempt to do this with reference to the issue of the social consequences of closing primary schools in rural areas.

68.   If humanity has a future at all, the issue of democracy will remain central to its political evolution.

69.   In addition, the automated check-in facility will alert readers to current issues of periodicals as soon as they are processed.