11.   Instead, they were taken aback when Rousseau suggested that their father be deeply sedated, letting him rest while the disease took its course.

12.   Once the disease takes hold throughout the body, most patients survive for about four years.

13.   Once the victim displays the primary symptom and sheds several hundred dollars buying a pup and supplies, the disease takes an ominous twist.

14.   Otherwise, the disease can take hold in patients, particularly AIDS sufferers whose immune systems are weakened.

15.   Prion diseases take many years to spread, incubate and produce symptoms, though once symptoms appear the disease usually progresses swiftly and is always fatal.

16.   The Abelows panicked, relaxing only after their pediatrician explained the many variations the disease can take.

17.   The disease generally takes years to develop silently.

18.   The disease takes at least two weeks to manifest itself, with a progressive loss of muscle coordination, a condition called ataxia.

19.   The disease took its toll on the youngster.

20.   The toll the disease is taking is enormous, Chitsulo said.