11.   Commuting difficulties have made developments in those areas less attractive.

12.   Technical difficulties made it impossible to salvage the wreckage and bury the victims.

13.   The difficulties have made Masako the object of widespread public sympathy in Japan.

14.   The difficulty is making a drug that gums up the IGF receptor but not the lookalike insulin receptor.

15.   Yet Volkswagen warned global economic difficulties will make it tough to beat the figure this year.