1.   No significant difference in total protein concentration was seen in gall bladder bile between the cholesterol gall stone patients and the gall stone free patients.

2.   Such a significant correlation, however, was absent in each bile sample taken from the cholesterol gall stone patients or gall stone free patients.

3.   There have been no studies reported, however, on the nucleation time of hepatic bile in gall stone free patients.

4.   In this study, hepatic bile of the cholesterol gall stone patients provided a significantly shorter nucleation time than that of the gall stone free patients.

5.   This indicates that cholesterol gall stone patients produce hepatic bile with a more reduced metastability of cholesterol compared with that of gall stone free patients.

6.   During the storage in the gall bladder, biliary metastability becomes further reduced only in the cholesterol gall stone patients and not in the gall stone free patients.

7.   Once stone free the patients were evaluated at six months interval.

8.   Stone free interval -- The median stone free interval between gall stone dissolution and trial entry was nine months.