1. Researchers are trying to sort out the difference in genetic make-up both in cancers and in normal tissue. 2. In contrast, amidated gastrins were found in similar concentrations in tumour and normal tissue, and concentrations were the lowest of those recorded in the four assays. 3. The antigen and activity concentrations of both plasminogen activators in normal tissue showed a steady increase going from squamous oesophagus to the stomach and duodenum. 4. Moreover, tissue type plasminogen activator antigen as well as tissue type plasminogen activator activity in oesophageal carcinoma tissue were not different from normal tissue concentrations. 5. The tissue type plasminogen activator antigen concentrations in both oesophageal carcinomas and stomach carcinomas were similar to those of the normal tissues. 6. This normal tissue injury is a limiting factor for radiotherapy dose. 7. Specific prophylactic inhibition of eicosanoid inflammatory mediators should be investigated as a way of limiting normal tissue injury to the rectum during pelvic radiotherapy. 8. Anther limiting factor in studying the properties of human gall bladder epithelium has been the lack of normal tissue. 9. Alternatively, many animal models have been used to overcome the lack of availability of normal human tissue. |