1. Much research in the pathophysiology of gall stones has been devoted to various molecular species of bile salts. 2. These and other variations in phospholipid molecular species shifted cholesterol among its carriers and also modified the nucleation time of model biles. 3. The effect of synthetic phosphalipids and different molecular species of phosphatidylcholine. 4. The difference can be explaiend by the molecular species of lecithins used. 5. Not only the total amount of phospholipids but also the molecular species has profound influences on cholesterol carriers and nucleation in bile. 6. Subjects with cholesterol gall stones were reported to have alterations in the molecular species of phosphatidylcholine in bile, although the results of various studies are conflicting. 7. In a recent study Cohen et al working with model solutions showed a non-even distribution of different molecular species of phosphatidylcholine between the vesicular and micellar carriers. |