1.   An advisory committee of the Food and Drug Administration recommended approval of the first such vaccine, but with ambivalence about its safety and effectiveness.

2.   Dr. Manuel Patarroyo, a Colombian biochemist, first met disbelief and ridicule when he claimed progress in developing the first successful vaccine against malaria.

3.   Even if the company gets its FDA approval, which could come in weeks or months, the first vaccines produced would be committed to military use.

4.   Federal health officials Wednesday licensed the first vaccine in the United States to prevent hepatitis A, a serious and common viral liver infection.

5.   In his new role, Francis hopes to speed development of what would be the first effective vaccine against HIV, the elusive virus that causes AIDS.

6.   It is the first human vaccine against the disease.

7.   It is the first vaccine for the AIDS virus to be widely tested in the United States.

8.   It would be the first vaccine for the bug.

9.   Similarly, he led the way with tests gaining the approval and wide use of the first vaccine against measles, once a threat to all children.

10.   Smith and Anderson made the first human vaccines against the disease, which were composed of pieces of the sugary coat of the bacterium bound to proteins.