1.   The Gastrointestinal Cancer Study Group carried out a number of randomised trials comparing FAM with other combination chemotherapy regimens.

2.   Combination therapy regimens are arguably the most demanding of any in medicine.

3.   The existing combination regimens are extremely demanding, in part because patients must swallow dozens of pills a day.

4.   The newer anti-HIV combination regimens that include drugs like protease inhibitors are far more powerful treatments for infected people than AZT alone.