11.   Recent studies have borne out claims that certain perfumes can bring about profound psychological changes.

12.   It is a reflection of profound underlying change in the way human society utilises information.

13.   Durkheim is perhaps the key protagonist of this dominant theme of profound social change.

14.   The new public management has wrought profound changes in the culture of public agencies, none more so than the NHS.

15.   The rapid introduction of microelectronics-based technologies has been widely predicted to bring about profound changes in many areas of life.

16.   And nowhere is that change more profound, or more confounding, than in cancer treatment.

17.   And the vote reflected the profound changes in German society that have followed the fall of the Berlin Wall.

18.   And this signals a profound change in the dynamic between the Americans, the Israelis and the Palestinians.

19.   Any step toward constitutionalism in the American sense would be a profound change.

20.   As much as anything, the strike reflects the profound changes that have swept Mexican society and politics in the past decade and a half.