11.   These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion.

12.   Platelet activating factor is on of lipid mediators that is generated in a variety of cells upon chemical or immune stimulation.

13.   It has been reported that pancreatic acinar cells, stimulated by caerulein or cholecystokinin, release substantial amounts of platelet activating factor.

14.   Emanuelli et al reported that an injection of platelet activating factor into the superior pancreaticoduodenal artery induced the changes in the rabbit pancreas characteristic of acute pancreatitis.

15.   Platelet activating factor was purchased from Bachem Feinchemikalien AG.

16.   The content of platelet activating factor in pancreatic tissue was determined using bioassay technique with washed rabbit platelets as described previously.

17.   Biological activity of platelet activating factor was measured by platelet aggregation using a Chrono-log Corporation aggregometer.

18.   These results provide evidence that platelet activating factor plays an important role in the progression of pancreatitis induced by the overstimulation of the pancreas with caerulein.

19.   Platelet activating factor also caused a marked decrease in the pancreatic blood flow comparable with that observed after caerulein infusion.

20.   Similar pancreatic injury was reported after the administration of platelet activating factor directly to the superior pancreaticoduodenal artery of rabbit.