41.  Moshe had suffered a second heart attack, this time a major one.

42.  Most studios, especially the major ones, try to avoid such a designation at any cost.

43.  Not all members of the alliance are equal, not even the major ones whose top executives have come to play a dominant role in the negotiations.

44.  Periodically scholars, journalists and idealists trumpet the idea that the time has finally arrived for a real third party to rival the two major ones.

45.  Schultz expects deals this year opening up other East Asian markets, and to eventually enter all the major ones.

46.  She and her doctors must watch for the risks associated with the transplant, the major one being that the new immune system could attack her healthy tissues.

47.  Such an adjustment is a major one, and one of those tiring warriors appears to be Tampa Bay running back Warrick Dunn.

48.  Suburbs present certain hazards for foxes, motor vehicles being a major one.

49.  That is only the first step toward sainthood, but it is a major one.

50.  The accident was the third major one at the site since construction began, and involved the second fatality.