11.  In severe cases, the skin can crack and weep.

12.  In the most severe cases, the disease can lead to blindness.

13.  Barium studies seem to be insensitive to microscopic involvement and may detect only more severe cases.

14.  Some patients may benefit from a stress management programme, while severe cases may require the multidisciplinary services of a pain clinic.

15.  In severe cases, when items block the fans altogether, damage to the mechanical parts can result.

16.  Nevertheless, in severe cases, pulmonary oedema and emphysema may occur and the lung surface may be studded with purulent areas of secondary infection.

17.  In more severe cases dyspnoea and tenacious nasal discharge are also present.

18.  Experts from the financial Peto Institute in Hungary told his parents, Alan and Evelyn, that he was probably too severe a case for them to tackle.

19.  Although many Americans think of Portland as the best-planned, best-managed city in the country, in Portland itself a severe case of self-doubt is setting in.

20.  Although he was sidelined briefly by a severe case of hemorrhoids soon after his record-breaking run last month, El Guerrouj appears back in form.