1.   Clearly, substantial changes are needed rather than tinkering.

2.   Even one extra user in a group would cause a substantial change in the known-unknown ratio.

3.   Green consumerism is a hopeful token of more substantial change.

4.   Substantial changes to medical education and research are outlined.

5.   The block exemptions are subject to review, since they have expiry dates written in, but no substantial change is imminent.

6.   These did not involve substantial changes, and often introduced useful clarifications and examples.

7.   The announcement, however, did not reflect a substantial change in the attitude of President Banda who remained steadfastly opposed to multiparty politics.

8.   We have again looked hard at our working practices and cost base and have made substantial changes.

9.   The Chancellor spent yesterday making substantial stylistic changes to the speech but the main elements were left untouched.