1.   The effects of bile on small bowel motility were studied in isolated, perfused rabbit terminal ileum.

2.   We used a model of isolated, perfused rabbit terminal ileum to characterise the effects of luminal bile salts on intestinal motility.

3.   Thus, luminal infusion of rabbit bile and TDCA inhibited motor activity in isolated segments of rabbit terminal ileum.

4.   This study showed that luminal infusion of bile and the bile acid TDCA inhibited carbachol stimulated motor activity in isolated segments of rabbit terminal ileum.