1. Amgen inserts the gene for making Epogen into Chinese hamster ovary cells, which then make the protein. 2. Amgen isolated the human gene for EPO and spliced that gene into hamster ovary cells, which churned out the protein in large enough quantities. 3. Amgen makes it by cloning the human gene for erythropoietin and putting it in hamster ovary cells that are grown in culture. 4. And suppose, further, that their ovary cells are more likely to produce eggs. 5. It clones the human gene governing the production of EPO and implants the gene into hamster ovary cells, which then make the protein. 6. She noted that it was approximately this dosage level that she used in her laboratory study that showed chromosome damage to Chinese hamster ovary cells. 7. The drug is made by cloning a human gene and splicing it into chinese hamster ovary cells. 8. When inserted into Chinese hamster ovary cells, it can cause them to produce large quantities of a hormone very similar to the hormone the human body naturally produces. 9. Amgen makes Epogen by putting cloned human genes into hamster ovary cells. 10. The U.S. Department of Agriculture fractures them into compounds that are applied one-by-one to the ovary cells of hamsters. |