1.   It was clearly shown that tissue type plasminogen activator activity was significantly correlated with the mucosal lesion.

2.   These results suggest the involvement of platelet activating factor in the endothelin induced fibrinolytic activation and subsequently developed mucosal haemorrhagic lesion.

3.   Sucralfate was effective against all three types of mucosal lesions.

4.   Sixty minutes after the last pulse, the rats were killed and their duodena subjected to evaluation of the mucosal lesions as detailed above.

5.   Bleeding from the small bowel may occur either from mucosal lesions or intramural lesions.