1.   The role of genes encoding other alcohol metabolising enzymes in a genetic predisposition to alcoholic liver damage has yet to be explored.

2.   Moreover, the same group of xenobiotic metabolising enzymes are probably involved in the development of colonic carcinoma.

3.   Biochemical studies of normal colonic epithelium have shown that several different xenobiotic metabolising enzymes have a low activity in colonic epithelium.

4.   There have been no extensive studies of xenobiotic metabolising enzyme expression in colonic adenomas.

5.   The overall phenotypic expression of different xenobiotic metabolising enzymes in colonic carcinomas is complex.