1.   No clear relation was found with degree of dysplasia, and no information was given pertaining to size or presence of malignant change.

2.   Total colectomy was performed because of incomplete removal of a large tubular adenoma with intra-epithelial malignant change.

3.   A further eight patients with villous adenomas but no evidence of malignant change were deemed unsuitable for the study and were given laser treatment only.

4.   The gene seems to play a pivotal role in suppressing malignant changes, and when it is inactivated the breast cells become much more prone to cancer.