1.   Debt and the destruction of war have brought major economic setbacks, aside from damage to social services and human suffering.

2.   Losing our key player would be a major setback for the team.

3.   Sadly, Rose suffered a major setback one day, when she had a grand mal epileptic fit.

4.   The defeat represented a major political setback for the conservatives.

5.   The space program suffered a major setback when the space shuttle, Discovery, exploded.

6.   This is not to deny that there were not some major setbacks.

7.   Without an efficient system and good professional advice, unforeseen problems can develop into major setbacks.

8.   The loss of their goalkeeper through injury was a major setback for the team.