1.   Discussion Our present studies implicate active oxygen and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by indomethacin.

2.   These reports suggested that inhibition of prostaglandin synthesis was unlikely to be sole mechanism responsible for the gastric damage induced by indomethacin.

3.   Our present studies implicate active oxygen and lipid peroxidation in the pathogenesis of gastric mucosal injury induced by indomethacin.

4.   Also, the treatment with SOD, SOD plus catalase, and DMSO significantly inhibited the pathological changes induced by indomethacin.

5.   The source of oxygen radicals in gastric mucosal injury induced by indomethacin in rats is not clear.