1.   Two patients had very high insulin concentrations before starting treatment, suggesting that they were not adequately fasted.

2.   Rosenbloom said while some people are insulin-sensitive, for most the notion that high insulin levels causes obesity is simplistic.

3.   The skin change signals high insulin levels in the body, which can be a warning sign of diabetes.

4.   Other signs of the condition can include high insulin levels, obesity, high blood pressure and excessive facial hair resulting from unusually high testosterone levels.