1. Briefly, the count of argyrophil cells and the count of raster points coinciding on the mucosa were calculated in areas of standard length and whole thickness of mucosa. 2. In five patients the nodules had disappeared and histological specimens showed only diffuse hyperplasia of argyrophil cells. 3. The severity of argyrophil cell hyperplasia was assessed, based on the number of argyrophil cell clusters per mm. 4. The density of argyrophil cells also varied considerably in individual patients without large changes in gastrin concentrations. 5. In patients with sporadic type disease, fundic argyrophil cells showed a normal pattern or diffuse or linear hyperplasia. 6. Proliferation of fundic argyrophil endocrine cells, mainly enterochromaffin like cells, is mostly under the control of gastrin in animals and in man. 7. On oxyntic tissue sections, argyrophil endocrine cells were stinaed with the Grimelius silver impregnation technique. 8. Means of argyrophil cell densities were also compared taking sex into consideration. 9. It has also been shown recently that, in patients with untreated duodenal ulcer, argyrophil cells were significantly more numerous in women than in men. 10. In patients with sporadic type Zollinger-Ellison sydrome, in addition to a normal pattern of argyrophil cells, cell hyperplasia was mainly diffuse. |
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