1.   The high rate of H pylori ammonia production in uraemic patients should accentuate any ammonia induced effects.

2.   The high intragastric urea concentrations in these patients greatly increas H pylori ammonia production which should accentuate any ammonia related effects.

3.   It has also been proposed that H pylori ammonia production will lead to mucosal damage by denaturing the protective mucus layer.

4.   This was demonstrated by the absence of any correlation between the severity of the gastritis or epithelial surface damage and the bacterial ammonia production.

5.   Triebling et al have recently claimed that ammonia production does play a pathogenic role in the development of H pylori related gastritis in man.

6.   In conclusion, this study shows that the very high rate of H pylori ammonia production in uraemic patients is not associated with more marked gastritis or hypergastrinaemia.