1. Cell adhesion and disease adhesion molecule deficiency A number of rare diseases result from defects in adhesion molecules. 2. However, the final, as yet small, family of cell adhesion molecules bind to carbohydrates. 3. This suggests a possible tumour suppressor function for this cell adhesion molecule. 4. Preliminary characterisation suggests that the gene product resembles a cell adhesion molecule and may therefore regulate the interaction of a cell with its environment. 5. An altered expression of such adhesion molecules may influence the aggressiveness of local infiltrative growth and metastasis in human cancers. 6. Besides an altered expression of integrin adhesion molecules in colorectal cancer, an altered function may also result in pathological cell matrix interactions. 7. Interferon may also synergise with TNF in several proinflammatory ways, increasing expression of adhesion molecules and MHC class I and II, and upregulating macrophage free radical production. 8. The adhesion molecules and receptors that mediate cell-matrix binding can be divided into two groups, the integrin and the non-integrin matrix receptors. 9. Brain cells use special proteins called cell adhesion molecules that help the cells stay in proper alignment for sending signals throughout the brain, Brentani said. 10. Adhesion molecules are a hot topic in heart disease research. |