71.   It seemed to them farfetched that clouds could have such a profound effect simply by shuttering the sky.

72.   It will have a profound effect on politics, but not in this cycle.

73.   Kreuter has built his career around being a strong defensive catcher, but the loss of Hundley could have a profound effect on the lineup.

74.   Lawrence Katz, a labor economist at Harvard, says that reducing the stigma attached to joblessness has profound effects on the labor market.

75.   Less obvious still is the profound effect that Central Park has had on other urban parks not encircled by multimillionaires.

76.   Like several others, he said the camp had had a profound effect on him.

77.   Losing population can have a profound effect on a place.

78.   Low inflation rates in Germany have a profound effect throughout Europe.

79.   Looking out over the Dublin Mountains in the distance, Jean Kennedy Smith acknowledges that the assassinations of her brothers have had a profound effect on her.

80.   Major changes such as canceling unprofitable routes, changing pricing structure, refinancing debts and renegotiating leases had profound effects, which seems obvious.