71.   Major drug companies stand to lose billions of dollars in sales in the next five years as patents expire and they face generic competition.

72.   Major drug makers and federal regulators are increasingly squaring off over problems at factories that could affect the quality of medicines being produced.

73.   Major drug trafficking routes pass through Laos.

74.   Minnesota Mining and Manufacturing Co. and two major drug companies, Bristol-Meyers Squibb and American Home Products Corp., reported double-digit earnings gains.

75.   Mexico has yet to extradite a major drug trafficker to the United States or to aggressively prosecute money-laundering operations, Nelson said.

76.   Ms. Williams, according to child welfare workers, had a major drug problem.

77.   None of the major drug makers bid on the contract.

78.   Not long ago a customer handed me prescriptions for two medications that have a major drug interaction.

79.   One of the cases involves a class action lawsuit brought by some U.S. drug store operators against major drug companies, alleging unfair pricing.

80.   Purcell said biotech companies increasingly would become aligned with major drug makers or combine resources with other enterprises focusing on similar disease or technology areas.