51.   At the time, the granting of annulments was limited to extreme cases involving severe mental illness and other unusual situations.

52.   Betablockers, for example, can cause gastrointestinal problems and even heart failure in extreme cases.

53.   Afghanistan is an extreme case.

54.   Agency officials could then decide whether to bar the contractor from further dealings with the government, and in an extreme case a contract could be terminated.

55.   But in extreme cases, like that of Zhao and her family, regulations are flouted.

56.   But it can lead to misunderstandings or, in extreme cases, charges of sexual harassment.

57.   But in extreme cases, parents who lean on their children may lose some authority in the arrangement, disrupting the family hierarchy.

58.   But now, Frankfurt has become the most extreme case of a performing institution in a major German city under siege.

59.   But that was an extreme case.

60.   But the program, which does not have much point outside of drawing attention to extreme cases, has a happy ending.